Nitrosigine is a ingredient of bonded arginine silicate. It has been shown to significantly boost nitric oxide (NO) levels, a key factor in increasing blood flow to working muscles.*Fast Acting Arginine Complex with Nitrosigine enhances arginine and silicon levels.* It takes effect in as quickly as 30 minutes and keeps delivering benefits up to 3 hours after a single dose.*Research shows that arginine is a useful supplemental nutrient to promote healthy endothelial function in healthy, aging individuals.*Trials have shown oral arginine supplementation contributes to enhanced exercise tolerance due to its ability to enhance cardiac circulation and vasodilation of the blood vessels.